The Nicollet Island-East Bank neighborhood comprises Nicollet Island on the Mississippi River just east of downtown and the portion of the eastern riverbank located between Central Avenue and the Burlington Northern Santa Fe Railroad line.
The neighborhood is at the geographical and historical center of Minneapolis.
Hennepin Avenue East and First Avenue Northeast are two of the main roads that connect the island to the rest of Minneapolis. The island spans 47 acres, and all but two of the houses on the island date from 1864 to 1898.
The island is part of the St. Anthony Falls Heritage District.